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Original Article
Novel influenza A (H1N1) 2009 infection in the pediatric patients with hematologic and oncologic diseases in the Yeungnam region
Seok Jeong Kang, Jae Min Lee, Jeong Ok Hah, Ye Jee Shim, Kun Soo Lee, Hyun Jung Shin, Heung Sik Kim, Eun Jin Choi, So Eun Jeon, Young Tak Lim, Ji Kyeong Park, Eun Sil Park
Clin Exp Pediatr. 2011;54(3):117-122.   Published online March 31, 2011
Purpose

Natural history and consequences of the novel 2009 influenza A H1N1 (2009 H1N1) infection in immunocompromised pediatric patients are not yet fully understood. In this study, we investigated the clinical features and outcomes of the 2009 H1N1 infection in pediatric patients with hematological and oncological diseases.

Methods

We retrospectively reviewed the medical records of 528 patients who had hematological and oncological diseases...

Prevalence and clinical significance of the positive antinuclear antibody in children with idiopathic thrombocytopenic purpura
So Eun Jun, Seong Sik Park, Young Tak Lim
Clin Exp Pediatr. 2008;51(11):1217-1221.   Published online November 15, 2008
Purpose : An association between idiopathic thrombocytopenic purpura (ITP) and systemic lupus erythematosus (SLE) has been recognized for decades because thrombocytopenia is the first manifestation in some patients with SLE. However, the risk of later development of SLE in childhood ITP is currently unknown. We retrospectively evaluated the incidence and clinical significance of the positive antinuclear antibody (ANA) in children...
Case Report
Change of neutrophil count after treatment of intravenous immunoglobulin in children with idiopathic thrombocytopenic purpura
Jun Young Park, Ji Ae Park, Seong Shik Park, Young Tak Lim
Clin Exp Pediatr. 2008;51(2):204-208.   Published online February 15, 2008
Purpose : The aim of this study was to investigate the incidence and course of neutropenia following intravenous immunoglobulin (IVIG) therapy in children with idiopathic thrombocytopenic purpura (ITP). Methods : From January 2001 to June 2006, fifty-four patients with ITP were enrolled in this study. Forty-two of 54 patients were treated with IVIG, while the other 12 were treated with...
Clinical Lecture
Differential Diagnosis and Treatment of Anemia in Children
Young Tak Lim
Clin Exp Pediatr. 2005;48(2):121-125.   Published online February 15, 2005
Anemia can be defined as a reduction in blood hemoglobin concentration or red cell mass relative to age matched normal values. Clinical presentation may range from obviously pale and lethargy to an incidental finding during screening of an otherwise well appearing child. The differential diagnosis of anemia in each instance is broad with numerous possible etiologies. A careful history and...
Case Report
A Case of Aplastic Anemia following Hepatic Failure by Acute Hepatitis
Hye Jin Ku, Young Tak Lim, Jae Hong Park
Clin Exp Pediatr. 2004;47(12):1356-1359.   Published online December 15, 2004
Aplastic anemia following acute hepatitis or acute hepatic failure is an uncommon disease and has a poor prognosis. We experienced a case of aplastic anemia following acute hepatic failure in a 10- year-old girl. She was admitted because of jaundice and lethargy for 8 days. Laboratory findings revealed marked elevated serum transaminases and bilirubin levels, prolonged prothrombin time and partial...
A Case of Shwachman-Diamond Syndrome
Jeong Won Kwak, Suk Kim, Young Tak Lim
Clin Exp Pediatr. 2004;47(8):900-903.   Published online August 15, 2004
Shwachman-Diamond syndrome(SD syndrome) is a rare genetic disorder chracterized by pancreatic insufficiency, short stature, skeletal abnormalities and bone marrow dysfunction. Exocrine pancreatic insufficiency and neutropenia are the main components of the syndrome. A hallmark of SD syndrome is varying severity of pancreatic dysfunction due to acinar maldevelopment. The hematologic abnormalities associated with SD syndrome include varying cytopenias, marrow aplasia, myelodysplasia...
Original Article
A Five-year Epidemiologic Study of Childhood Leukemia in Busan City, 1996 to 2000
Jae Hoon Moon, Soon Yong Lee, Jong Beom Sinn, Jae Sun Park, Young Ho Lee, Young Tak Lim, Su Eun Park
Clin Exp Pediatr. 2003;46(10):972-976.   Published online October 15, 2003
Purpose : For the control of childhood leukemia, of which the mortality is still high, the basic data for the incidence has a great importance. The authors analyzed the data from 133 new patients with childhood leukemia between 1996-2000 in Busan, Korea. Methods : The data were obtained from 133 new cases(87 males and 46 females from 0 to 15 years...
The Study of the Changes of Myocardial Histology and Left Ventricular Function according to the Total Doses of Doxorubicin in Rabbits
Jeong Hwa Choi, Hee Ju Park, Young Tak Lim, Bong Seon Kim, Eun Young Huh
Clin Exp Pediatr. 2001;44(12):1395-1403.   Published online December 15, 2001
Purpose : We'd like to evaluate the relationship between the degree of cardiac damage and that of cardiac function according to the total injected dose of doxorubicin. Methods : 12 rabbits(body weight : 2.0-3.2 kg) were used and 30 mg/m2/week of doxorubicin hydrochloride was injected intravenously. The cardiac function was checked under anesthesia, after which the thorax was opened and cardiac samples were evaluated...
Hemostatic Changes and Effect of Antithrombin Ⅲ Replacement Therapy in Children with Acute Lymphoblastic Leukemia
Jeong Ah Choi, Young Tak Lim
Clin Exp Pediatr. 1999;42(11):1567-1573.   Published online November 15, 1999
Purpose : We evaluated plasma coagulation parameters sequentially and the influence of antithrombin Ⅲ adjuvant treatment in children with acute lymphoblastic leukemia. Methods : Twenty-nine cases with acute lymhoblastic leukemia who had been treated with L-asparaginase at Pusan National University Hospital were enrolled in this study. The coagulation parameters were checked before and on every week of L-asparaginase administration. The...
The Effect of Empirical Antibiotics in Febrile Neutropenia
Ju Suk Lee, Young Tak Lim
Clin Exp Pediatr. 1998;41(9):1209-1215.   Published online September 15, 1998
Purpose : This study was designed to evaluate the safety and efficacy of early cessation of antibiotic treatment regardless of absolute neutrophil count in children with febrile neutropenia and no identifiable infectious source. Methods : A prospective randomized clinical trial was performed in 93 episodes of fever in 37 neutropenic children with cancer, who were admitted to the Department of...
Correlation Between Clinical and Pathological Prognositic Factors of IgA Nephropathy in Children
Hwang Jae Yoo, Bon Su Ku, Young Tak Lim, Su Yung Kim
Clin Exp Pediatr. 1998;41(8):1093-1101.   Published online August 15, 1998
Purpose : Clinical and pathological prognostic factors of idiopathic IgA nephropathy have been reported, but mostly in adults and a few in children. Especially studies about correlation between those factors are very rare. Methods : We studied 58 children patients who were hospitalized to our clinics and diagnosed as IgA nephropathy by renal biopsy from Jan. 1989 to Jun 1996. They...
Immunohistochemical Study of Bcl-2 Oncoprotein Expression in Childhood Non-Hodgkin's Lymphoma
Sung Mee Kim, Jin Hwa Jung, Jeong Ho Lee, Jong Dae Jo, Young Tak Lim, Do Youn Park, Sun Kyeung Lee
Clin Exp Pediatr. 1997;40(9):1265-1274.   Published online September 15, 1997
Purpose : The aim of the present study was to assess the clinicopatholgical significance of Bcl-2 oncoprotein expression in childhood non-Hodgkin' s lymphoma(NHL). Methods : We have assessed 16 cases of childhood NHL during last 6 years from 1990 to 1995. Bcl-2 oncoprotein expression has been semiquantitatively analyzed in paraffin sections from 16 cases of childhood NHL with 39 control cases of adult NHL. The...
Medical Lecture Course
The Role of Proteinases in Tumor Invasion and Metastasis
Young Tak Lim
Clin Exp Pediatr. 1997;40(7):901-907.   Published online July 15, 1997
Case Report
A Case of Distal Rental Tubular Acidosis with Systemic Lupus Erythematosus (SLE)
Jeong Hwa Choi, Sung Hun Kim, Young Tak Lim, Su-Yung Kim
Clin Exp Pediatr. 1997;40(1):134-139.   Published online January 15, 1997
Original Article
Correlation between Plasma Endothelin-1 Concentrations and Pulmonary Hypertension Associated with Congenital Heart Defects
Sang Ook Park, Su Eun Park, Hyang Jae Yoo, Young Tak Lim, Hee Ju Park
Clin Exp Pediatr. 1996;39(7):970-976.   Published online July 15, 1996
Purpose : Endothelin-1 is the most potent vasoconstrictor. This study was investigated the correlation of plasma endothelin-1 and pulmonary hypertension associated with congenital heart defect. Methods : We evaluated the concentration of ET-1 in 24 cases of congenital heart disease diagnosed at the Department of Pediatrics, Pusan National University, from December 1993 to September 1994. The patients were divided into 2 groups according to mean...
Case Report
A Case of Ring 14 Chromosome Syndrome
Jeong Hwa Choi, Han Sang Cho, Young Tak Lim, Hee Ju Park
Clin Exp Pediatr. 1995;38(11):1583-1587.   Published online November 15, 1995
A case of ring 14 chromosome syndrome, confirmed by chromosome study, was dis¡ⓒ cribed. She was 15 months old and manifestated facial abnormalities containing micro¡ⓒ cephaly, flat occiput, hyperterrorism and psychomotor retardation, intractable seizure. Chromosomal study showed the ring 14 chromosome, karyotypic ally she was depicted 46, XY, r(14). A brief review of all literature was also presented.
A Case of Eosinophilic Gastroenteritis in a Child
Young Don Kim, Jung Hwa Choi, Young Tak Lim, Hee Ju Park
Clin Exp Pediatr. 1995;38(4):552-556.   Published online April 15, 1995
Eosinophilic gastroenteritis is an uncommon disorder of the stomach, small bowel, and colon, characterized by eosinophilic infiltration of the gut wall and peripheral blood eosinophilia. The clinical features depend on the site of eosinophilic infiltration. Patients with eosinophilic gastroenteritis may develop an exudative ascites containing eosinophils. We experienced a case of eosinophilic gastroenteritis in a 9 year old boy who had...
Original Article
Two Cases of Congenital Asplenia.
Man Chul Ha, Young Tak Lim, Hi Joo Chun, Hi Ju Park, Chan Yung Kim
Clin Exp Pediatr. 1987;30(8):916-921.   Published online August 31, 1987
Congenital absence of spleen is often associated with malpositions and malformations of other organ system such as congenital heart disease partial situs inversus, symmetric lobulation of the liver and the lungs. This is a rare syndrome but has been reported in increasing frequency in recent years. The pure congenital asplenia is a very rare disease. We experienced two cases of congenital asplenia. One is...
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